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    杜少军

    时间:2010-01-22 11:47:02 点击:

    杜少军,1993年获加拿大多伦多大学生化与分子生物学博士学位,1993-1997年在美国华盛顿大学-Howard Hughes 医学研究所从事博士后研究,2006 获中国国家自然科学基金委J-B奖。现任马里兰大学生化与分子生物学系副教授(终身),主要从事鱼类分子生物学,发育生物学研究,在鱼类生长与发育调控机制的基础研究及生物技术在水产养殖中应用研究方面,获得美国国家发明专刊1项,在国外刊物发表论文共30多篇,其中包括论文发表在 Nature Biotechnology ,PloS one PNAS

    (1)代表性论著(论文)

    发表时间

    论著(论文)名称

    发表载体

    论著(论文)作者

    1992

    Growth enhancement in transgenic Atlantic salmon by the use of an

    "all fish" chimeric growth hormone gene construct.

    Nature Biotechnology

    D

    , S. J., Gong, Z., Fletcher, G., Shears, M. A., King, M. J., Idler, D. R. and Hew*,

    C. L.

    1993

    Genomic structure of growth hormone genes in chinook salmon (Oncorhynchus tshawytscha): presence of two functional genes, GH-I and GH-II, and a male-specific pseudogene, GH-Ψ.

    DNA and Cell Biology

    Du, S. J., Devlin, R. H. and Hew*, C. L.

    1995

    Production of germline transgenic Pacific salmonids with dramatically increased growth performance

    Canadian Journal of Fisheries and Aquatic Sciences

    Devlin, R. H., Yesaki, T. Y., Donaldson, E. M., Du, S. J. and Hew*, C. L

    1995

    Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos.

    Molecular and Cellular Biology

    Du, S. J., Purcell, S. M., Christian, J. L., McGrew, L. L. and Moon*, R. T.

    1997

    Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-βgene families.

    J. Cell Biol.

    Du,S.J., Devoto,S., Westerfield, M., and Moon*, R. T.

    2000

    Gli2 mediation of hedgehog signals in slow muscle indu

    tion in zebrafish.

    Differentiation.

    Du*, S.

    . and Dienhart, M.

    2001

    Visualizing normal and defective bone

    evelopment in zebrafish embryos using the fluorescent chromophore calcein.

    Developmental Biology.

    Du*, S. J., Frenkel, V., Kindschi, G. and Zohar Y.

    2001

    The zebrafish tiggy-winkle hedgehog promoter directs notochord and floor plate GFP expression in transgenic zebrafish embryos.

    Developmental Dynamics

    Du*, S. J. and Dienhart, M.

    2002

    Differential expression of two myod genes in fast and slow muscles of gilthead seabream (sparus aurata).

    Development Genes and Evolution

    Tan, X. and Du*, S. J.

    2002

    Characterization of muscle-regulatory genes, myf5 and myogenin, from striped bass and promoter analysis of muscle-specific expression.

    Marine Biotechnology

    Tan, X., Hoang, L. and Du*, S. J.

    2003

    Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter.

    Comparative Biochemistry and Physiology: B

    Du*, S. J., Gao, J., and Victor, Anyangwe.

    2003

    Analysis of myostatin gene structure, expression and function in zebrafish.

    J. Exp. Biol.

    Xu, C., Wu, G., Zohar, Y., and  Du*, S. J.

    2006

    SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.

    Proc. Natl. Academy. Sci. USA.

    Tan, X., Rotllant, J., Li, H., DeDeyne, P. and Du*, S. J.

    2006

    The zebrafish smyd1 promoter directs muscle-specific GFP expression in transgenic zebrafish embryos.

    Developmental Dynamic.

    Du*, S. J., Rotllant, J., and Tan, X.

    2008

    Heat shock protein 90a1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.

    Proc. Natl. Academy. Sci. USA.

    Du*, S. J., Li, H., Bian Y. H., and Zhong, Y

    2008

    Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear.

    Matrix Biology.

    Rotllant,* J., Liu D., Yan Y. L.,  Postlethwait J. H., Westerfield, M. and Du S.J.

    2009

    skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization.

    FASEB J.

    Li, H., Randall, W., and Du*, S. J.

    2009

    Analyzing notochord segmentation and intervertebral disc formation using the twhh:gfp transgenic zebrafish model.

    Transgenic Research.

    Haga, Y., Dominique, V., and Du*,S. J.

    2010

    Loss of Smyhc1 or Hsp90a1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.

    PLoS ONE.

    Codina M, Li J., Gutiérrez, J., Kao J., and Du*, S. J.

    2010

    Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.

    BMC Cell Biology.

    Bernick, B, Zhang, P. J.,  and Du*, S. J.

     

    (2)专利

    专利保护期

    专利名称

    授权国家

    专利所有者

    1996-present

    Determination of genetic sex in salmonids

    USA

    Choy Hew and

    Shao jun Du

     
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